Abstract Search

ea0077oc1.2 | Reproductive and Neuroendocrinology | SFEBES2021

Hyper-phosphorylation of β-catenin at Serine552 correlates with invasion and predicts recurrence of Non-Functioning Pituitary Tumours (NFPTs)

Rai Ashutosh , Yelamanchi Soujanya D. , Radotra Bishan D , Gupta Sunil K , Chhabra Rajesh , Pandey Akhilesh , Korbonits Marta , Gaston-Massuet Carles , Dutta Pinaki

Background: No predictive biomarkers for NFPT recurrence have been identified, apart from Ki67. We employed high-throughput mass spectrometry-based analyses to examine the phosphorylation pattern of different subsets of NFPTs. Methods: Based on histopathological, radiological and surgical features, NFPTs were sub-grouped into three groups: non-invasive (n = 15), invasive (n = 10) and recurrent (n = 5) subtypes. Invasiveness was...

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ea0086op3.2 | Reproductive and Neuroendocrinology | SFEBES2022

Identification of differentially activated pathways in recurrent non-functioning pituitary tumours using quantitative proteomics and bioinformatics analysis

Rai Ashutosh , Yelamanchi Soujanya D , Barry Sayka , Radotra Bishan D , Gupta Sunil K , Chhabra Rajesh , Pandey Akhilesh , Korbonits Marta , Dutta Pinaki

Background: No predictive biomarkers have been identified for clinically nonfunctioning pituitary tumour (NFPT) recurrence, with Ki67 being controversial. We employed quantitative mass spectrometry-based analyses to examine the differential expression of proteins in NFPTs.Methods: NFPTs were sub-grouped: non-invasive/non-recurrent group (NI/NR-G, n=5), invasive group (I-G, n=10) and recurrent group (R-G, n=5). Invasiveness was ...

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Endocrine Abstracts

Hyper-phosphorylation of β-catenin at Serine552 correlates with invasion and predicts recurrence of Non-Functioning Pituitary Tumours (NFPTs)

Identification of differentially activated pathways in recurrent non-functioning pituitary tumours using quantitative proteomics and bioinformatics analysis

BiosciAbstracts